Regardless of which state's law applies, the administrative license clock is the most time-sensitive piece. Missouri's 15-day DOR hearing request runs from receipt of the notice of suspension, and Illinois's Petition to Rescind must be filed within 90 days of notice to preserve the challenge, though the suspension itself begins on day 46. Both clocks start earlier than the first court appearance. Most clients call after the criminal court date is set, which is often too late on the Missouri side in particular. Calling within the first week of the arrest preserves both tracks.
Cannabis cases are where the substantive law diverges most sharply. A Missouri cannabis DWI defended on totality-of-evidence terms is a fundamentally different case than an Illinois cannabis DUI prosecuted on per-se grounds at 5 ng/mL. Frequent users (including medical-cannabis patients on either side of the river) should know that an Illinois traffic stop with any cannabis use in the prior 24-48 hours creates per-se exposure that does not exist on the Missouri side.
Repeat-offense exposure is the second area where the difference is severe. Illinois counts DUI priors for life. Missouri's persistent-offender determinations have a 10-year lookback for some enhancements but lifetime relevance for others. A second offense in either state is significantly worse than a first; in Illinois, a second offense with aggravators (school zone with injury, license suspended for prior DUI, etc.) is a felony with mandatory prison exposure.